By Ivana Pantelic
The on-going ‘green’ pattern within the own care coupled with international environmental matters, position natural-origin, biodegradable and skin-friendly surfactants akin to alkyl polyglucosides (APGs) in excessive call for. After winning use in cosmetics, adequate information has been got to welcome a few sugar emulsifiers into the sector of drug dosage. Alkyl Polyglucosides offers a finished compendium which publications a researcher from the APG-related preformulation levels to formula processing, together with the research of varied APG-stabilized platforms pores and skin functionality. This publication introduces quite a few APG representatives, their merits in terms of sure traditional surfactants, physicochemical and interfacial homes, attainable interplay with everyday components and numerous characterization strategies fundamental for the review of colloidal structures. the 1st bankruptcy introduces alkyl polyglucosides, via chapters on their houses, behaviour, an summary of the patent defense mechanisms and directions for filing patent functions. ultimately, a end surveys foreign patent functions regarding APGs.
- introduces the sphere of alkyl polyglucoside emulsifiers, directory the entire modern and newly synthesized APG emulsifiers
- provides precise details on a number of facets of APG-based buildings
- reveals capability of APG-stabilized autos as potential supply structures utilizing numerous version medications and beauty actives
- includes an updated assessment of study performed within the box of APGs, facilitating destiny preformulation and formula reports for researchers
- offers a concise and sensible compendium of characterization suggestions
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Extra resources for Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems
Weinheim: VCH, 1997. Mehling A, Hensen H. Comparative studies on the irritation potential of surfactants. Exog Dermatol 2004; 191–200. Mehling A, Kleber M, Hensen H. Comparative studies on the ocular and dermal irritation potential of surfactants. Food Chem Toxicol 2007; 45: 747–58.
APGs are synthesized by direct reaction of glucose with fatty alcohol, using a large excess of alcohol in order to minimize sugar oligomerization (Hill, 2008). At the moment, there are a considerable number of APGs available on the market. Some of them are already finding wide application in personal and skin care products, or even in prospective pharmaceutical applications: ■ C8-10 fatty alcohol glucoside (Plantacare® 810 UP, Cognis/BASF, Germany); ■ C8-14 fatty alcohol glucoside (Glucopon® 425 NH/H, Cognis/BASF, Germany); ■ C10-16 fatty alcohol glucoside (Glucopon® 600 CS UP, Cognis/BASF, Germany); ■ C12-16 fatty alcohol glucoside (Plantacare® 1200 UP, Cognis/BASF, Germany); ■ Myristyl glucoside and Myristyl alcohol (Montanov™ 14, Seppic, France); 25 Alkyl Polyglucosides ■ Coco glucoside and Cetearyl alcohol (Montanov™ 82, Seppic, France); ■ Cetearyl glucoside and Cetearyl alcohol (Montanov™ 68 or Sepineo™ 68, Seppic, France); ■ Arachidyl glucoside and Arachidyl behenyl alcohol (Montanov™ 202, Seppic, France); ■ Hydroxystearyl glucoside and Hydroxystearyl alcohol (Simulgreen™ 18-2, Seppic, France).
It was postulated that this molecule, belonging to the group of amphiphile glucolipids, could form both the thermotropic liquid crystalline phases in their pure state upon heating and the lyotropic liquid crystalline phases upon addition of a solvent (Stubenrauch, 2001). At that time there was a lack of comprehensive data on mesomorphic behaviour of long-alkyl-chain glycosides, combined with fatty alcohols, in the form of well-known mixed emulsifiers. , 2005b) assessing a series of binary (emulsifier/water) and ternary systems (emulsifier/water/oil) prepared using fixed ratios of components and medium-chain triglycerides as the oil phase.